You mean from this site? Yeah, I go through everytime it hits 200 or so and mark them all as read. That way, I don't have to scroll through a thousand emails to pick out the ones I actually need to read/reply to.
Yeah, I try to go through every 200 or so. Scanning 200 doesn't take very long, but when it hits 700 or so, it gets annoying, because of course all the emails I actually need to reply to always hide between the ones from here. If not much else is going on and it's slow (like right now), I'll just mark them as they come.